UPDATE! Aerosol School 2022 was to be held Oct 19-21, but has had to be postponed due to a number of factors.
We are considering holding a virtual program in the spring of 2023.
Watch this space for further updates.

Program Schedule

Day 1 - Wednesday, October 19, 2022

Lectures will be in Campbell and Miller Auditoriums, 2nd Floor, Juravinski Tower. Lab 1 will be in Classroom B, 2nd Floor Tower; Labs 2 and Lab 3 in F132 - Firestone Research Aerosol (FRAL), 1st Floor Fontbonne Bldg.

Time Talk Aerosol School Presentation Location Speaker Documents
8:30 - 9:15am Welcome - Introduction of Faculty, Attendees, Program Campbell Auditorium M Dolovich
9:15 - 10:00am 1 Aerosol Drug Delivery Devices J Fink
10:00 - 11:30am 2 Device Showcase - MDIs, Spacers, DPIs, Nebulizers Classroom B J Fink
M Dolovich
L Mao
J Mitchell
Lab 1
11:15 - 11:45am Refreshment Break (during Device Showcase)
11:45 - 12:30pm 3 Inhalation and formulation development Campbell Auditorium L Mao
12:30 - 1:15pm Lunch Talks 4-6 on M Stick
1:15 - 2:00pm 7 Real World Considerations for Experimental Design Campbell Auditorium A Goodey
2:00 - 2:45pm 8 How to Interpret Results and Recognize Bias Campbell Auditorium M Inman
2:45 - 3:30pm 9 Aerosol Measurements For OINDP Quality Assessment: 1. Delivered Dose Uniformity (DDU) Campbell Auditorium J Mitchell Sources: Ther. Deliv. article: "Improved Laboratory Test Methods for Orally Inhaled Product" JAMPDD article: "Appropriate face models for evaluating drug delivery in the laboratory: The current situation and prospects for future advances"
3:30 - 3:45pm 10 LAB Protocol: unit doses
Organize teams
F132 Fontbonne C Ruzycki Sources: (Chapter <601>, etc)
4:00 - 6:15pm 11
12
LAB
- Unit Dose Measurements
- Results from measurements
F132 Fontbonne C Ruzycki
S Tavernini
J Mitchell
L Mao
Lab 2
7:00pm Reception (Staybridges Hotel)

Day 2 - Thursday, October 20, 2022

- Lab 3 will be in the Firestone Research Aerosol (FRAL) F132
- Lectures will be in the Campbell Auditorium, 2nd Floor Juravinski Auditorium.

Time Talk Aerosol School Presentation Location Speaker Documents
8:30 - 9:30am 13 Particle Size Measurements for OINDP Quality-Control (Qc): Part 2: Aerodynamic Particle Size Distribution (APSD)
(a) cascade impactor
(b) overview of methods for APSD
(c) frequently encountered Cis
(d) accessories for the CI
(e) measurement accuracy and precision
(f) Methods for nasal spray products
Campbell Auditorium J Mitchell Sources: USP <601>, <1601> Ph.Eur. 2.9.18, 2.9.44 CAN/CSA/Z264.1-02:2008 EPAG, IPAC-RS and PQRI papers on GCIPC
9:30 - 10:30am 14 Inhaled, nasal sprays and formulation development Campbell Auditorium L Mao
10:30 - 11:30am 15 Bacteriophages as surrogates for infectious viral aerosols: generation and characterization Campbell Auditorium Z Hosseinidoust
11:30 - 12:30pm 16 Clinically Appropriate Methods for Performance Testing of OIPs
(a) Rationales for such testing
(b) Breathing simulation
(c) Delayed inhalation
(d) Inlet Design
(e) OIPs with a facemask
(f) Interfacing the cascade impactor with breath simulation
(g) Simulation of disease
Campbell Auditorium J Mitchell
12:30 - 1:30pm Lunch (Classroom B - Juravinski Tower )
1:30 - 3:30pm 18 LAB - particle sizing measurements (MDI, DPI, Liquids, nasal pumps) F132 Fontbonne J Fink
J Mitchell
L Mao
L Jordan
C Ruzycki
S Tavernini
Lab 3
Vendor Catalogues: Copley, MSP Corp, , Proveris - Sprayview
3:30pm Group Photo
3:30 - 3:45pm Refreshment Break
3:45 - 5:00pm 18 LAB 3 cont'd F132 Fontbonne J Fink
J Mitchell
L Mao
L Jordan
C Ruzycki
S Tavernini
Lab 3
5:00 - 6:30pm 19 Analysis of Impactor Data: Calculations, Spreadsheets F132 Fontbonne A Goodey
J Mitchell
C Ruzycki
Lab 3
Sources: computer software; (Chapter <601>, CSA Spacer Standard)
20 Online tutorial for APSD Measurements A Goodey
6:45pm Group Dinner (La Piazza Allegra - 180 James St S, Hamilton)

Day 3 - Friday, October 21, 2022

Lectures will be in Miller Auditorium, 2nd Floor Juravinski Tower.

Time Talk Aerosol School Presentation Location Speaker Documents
9:00 - 10:00am 21 Particle Size Measurements for OINDP Quality-3: Alternatives to the cascade impactor:
(a) Laser diffraction
(b) Light scattering, including Laser (phase) Doppler
(c) Time-of-Flight
(d) Microscopy-Raman Chemical Imaging
Miller Auditorium J Mitchell Sources: ISO 27427 USP<1601> Ph.Eur. 2.9.44 IPAC-RS paper on non CI methods
10:00 - 11:00am 22 Development of inhalable mAb formulations Miller Auditorium M Gomez
11:00 - 12:00pm 23 In Vitro / In Vivo Correlation (IVIVC): Measurements and Simulations to Estimate Aerosol Drug Delivery Miller Auditorium J Fink
12:15 - 1:30pm Lunch
1:30 - 2:15pm 24 Delivering Drugs to the Nose in Health and Disease Miller Auditorium H Neighbour Video Presentation
2:15 - 3:15pm 25 In vitro methods for assessing nasal drug products Miller Auditorium A Martin
3:15 - 4:00pm 26 Relationships between laboratory measurements, imaging of particle deposition in the HRT, pharmacokinetic and pharmacodynamic data Miller Auditorium M Dolovich
J Mitchell
ISAM Consensus paper in JAMPD on BE: "Demonstrating Bioequivalence of Locally Acting Orally Inhaled Drug Products (OIPs);: Workshop Summary Report"; PQRI and ISAM/AAPS Workshops; Orlando Inhalation Conference 2014; Articles covering special case of spacers/VHCs
4:00 - 4:30pm 27 Roles of the Pharmacopeias, National and International Standards and Regulatory Guidance documents in OINDP Assessments:
(a) Purpose
(b) Stakeholder relationships
(c) Current situation


Future developments, including informative rather than normative guidance
Miller Auditorium J Mitchell USP and Ph.Eur. chapters covering OINDP; ISO 20072 and 27427; FDA, HC and EMA Guidamces covering OINDP
4:30 - 5:00pm Wrap up - Q&A Miller Auditorium Evaluation Forms and Certificates