UPDATE! Aerosol School 2022 was to be held Oct 19-21, but has had to be postponed due to a number of factors.
We are considering holding a virtual program in the spring of 2023.
Watch this space for further updates.
Program Schedule
Day 1 - Wednesday, October 19, 2022
Lectures will be in Campbell and Miller Auditoriums, 2nd Floor, Juravinski Tower. Lab 1 will be in Classroom B, 2nd Floor Tower; Labs 2 and Lab 3 in F132 - Firestone Research Aerosol (FRAL), 1st Floor Fontbonne Bldg.
| Time | Talk | Aerosol School Presentation | Location | Speaker | Documents |
| 8:30 - 9:15am | Welcome - Introduction of Faculty, Attendees, Program | Campbell Auditorium | M Dolovich | ||
| 9:15 - 10:00am | 1 | Aerosol Drug Delivery Devices | J Fink | ||
| 10:00 - 11:30am | 2 | Device Showcase - MDIs, Spacers, DPIs, Nebulizers | Classroom B | J Fink M Dolovich L Mao J Mitchell |
Lab 1 |
| 11:15 - 11:45am | Refreshment Break (during Device Showcase) | ||||
| 11:45 - 12:30pm | 3 | Inhalation and formulation development | Campbell Auditorium | L Mao | |
| 12:30 - 1:15pm | Lunch | Talks 4-6 on M Stick | |||
| 1:15 - 2:00pm | 7 | Real World Considerations for Experimental Design | Campbell Auditorium | A Goodey | |
| 2:00 - 2:45pm | 8 | How to Interpret Results and Recognize Bias | Campbell Auditorium | M Inman | |
| 2:45 - 3:30pm | 9 | Aerosol Measurements For OINDP Quality Assessment: 1. Delivered Dose Uniformity (DDU) | Campbell Auditorium | J Mitchell | Sources: Ther. Deliv. article: "Improved Laboratory Test Methods for Orally Inhaled Product" JAMPDD article: "Appropriate face models for evaluating drug delivery in the laboratory: The current situation and prospects for future advances" |
| 3:30 - 3:45pm | 10 | LAB Protocol: unit doses Organize teams |
F132 Fontbonne | C Ruzycki | Sources: (Chapter <601>, etc) |
| 4:00 - 6:15pm | 11 12 |
LAB - Unit Dose Measurements - Results from measurements |
F132 Fontbonne | C Ruzycki S Tavernini J Mitchell L Mao |
Lab 2 |
| 7:00pm | Reception (Staybridges Hotel) | ||||
Day 2 - Thursday, October 20, 2022
- Lab 3 will be in the Firestone Research Aerosol (FRAL) F132
- Lectures will be in the Campbell Auditorium, 2nd Floor Juravinski Auditorium.
| Time | Talk | Aerosol School Presentation | Location | Speaker | Documents |
| 8:30 - 9:30am | 13 | Particle Size Measurements for OINDP Quality-Control (Qc): Part 2: Aerodynamic Particle Size Distribution (APSD) (a) cascade impactor (b) overview of methods for APSD (c) frequently encountered Cis (d) accessories for the CI (e) measurement accuracy and precision (f) Methods for nasal spray products |
Campbell Auditorium | J Mitchell | Sources: USP <601>, <1601> Ph.Eur. 2.9.18, 2.9.44 CAN/CSA/Z264.1-02:2008 EPAG, IPAC-RS and PQRI papers on GCIPC |
| 9:30 - 10:30am | 14 | Inhaled, nasal sprays and formulation development | Campbell Auditorium | L Mao | |
| 10:30 - 11:30am | 15 | Bacteriophages as surrogates for infectious viral aerosols: generation and characterization | Campbell Auditorium | Z Hosseinidoust | |
| 11:30 - 12:30pm | 16 | Clinically Appropriate Methods for Performance Testing of OIPs (a) Rationales for such testing (b) Breathing simulation (c) Delayed inhalation (d) Inlet Design (e) OIPs with a facemask (f) Interfacing the cascade impactor with breath simulation (g) Simulation of disease |
Campbell Auditorium | J Mitchell | |
| 12:30 - 1:30pm | Lunch (Classroom B - Juravinski Tower ) | ||||
| 1:30 - 3:30pm | 18 | LAB - particle sizing measurements (MDI, DPI, Liquids, nasal pumps) | F132 Fontbonne | J Fink J Mitchell L Mao L Jordan C Ruzycki S Tavernini |
Lab 3 Vendor Catalogues: Copley, MSP Corp, , Proveris - Sprayview |
| 3:30pm | Group Photo | ||||
| 3:30 - 3:45pm | Refreshment Break | ||||
| 3:45 - 5:00pm | 18 | LAB 3 cont'd | F132 Fontbonne | J Fink J Mitchell L Mao L Jordan C Ruzycki S Tavernini |
Lab 3 |
| 5:00 - 6:30pm | 19 | Analysis of Impactor Data: Calculations, Spreadsheets | F132 Fontbonne | A Goodey J Mitchell C Ruzycki |
Lab 3 Sources: computer software; (Chapter <601>, CSA Spacer Standard) |
| 20 | Online tutorial for APSD Measurements | A Goodey | |||
| 6:45pm | Group Dinner (La Piazza Allegra - 180 James St S, Hamilton) | ||||
Day 3 - Friday, October 21, 2022
Lectures will be in Miller Auditorium, 2nd Floor Juravinski Tower.
| Time | Talk | Aerosol School Presentation | Location | Speaker | Documents |
| 9:00 - 10:00am | 21 | Particle Size Measurements for OINDP Quality-3: Alternatives to the cascade impactor: (a) Laser diffraction (b) Light scattering, including Laser (phase) Doppler (c) Time-of-Flight (d) Microscopy-Raman Chemical Imaging |
Miller Auditorium | J Mitchell | Sources: ISO 27427 USP<1601> Ph.Eur. 2.9.44 IPAC-RS paper on non CI methods |
| 10:00 - 11:00am | 22 | Development of inhalable mAb formulations | Miller Auditorium | M Gomez | |
| 11:00 - 12:00pm | 23 | In Vitro / In Vivo Correlation (IVIVC): Measurements and Simulations to Estimate Aerosol Drug Delivery | Miller Auditorium | J Fink | |
| 12:15 - 1:30pm | Lunch | ||||
| 1:30 - 2:15pm | 24 | Delivering Drugs to the Nose in Health and Disease | Miller Auditorium | H Neighbour | Video Presentation |
| 2:15 - 3:15pm | 25 | In vitro methods for assessing nasal drug products | Miller Auditorium | A Martin | |
| 3:15 - 4:00pm | 26 | Relationships between laboratory measurements, imaging of particle deposition in the HRT, pharmacokinetic and pharmacodynamic data | Miller Auditorium | M Dolovich J Mitchell |
ISAM Consensus paper in JAMPD on BE: "Demonstrating Bioequivalence of Locally Acting Orally Inhaled Drug Products (OIPs);: Workshop Summary Report"; PQRI and ISAM/AAPS Workshops; Orlando Inhalation Conference 2014; Articles covering special case of spacers/VHCs |
| 4:00 - 4:30pm | 27 | Roles of the Pharmacopeias, National and International Standards and Regulatory Guidance documents in OINDP Assessments: (a) Purpose (b) Stakeholder relationships (c) Current situation Future developments, including informative rather than normative guidance |
Miller Auditorium | J Mitchell | USP and Ph.Eur. chapters covering OINDP; ISO 20072 and 27427; FDA, HC and EMA Guidamces covering OINDP |
| 4:30 - 5:00pm | Wrap up - Q&A | Miller Auditorium | Evaluation Forms and Certificates | ||